Of Mice and Men is a 1992 American period drama film based on John Steinbeck's 1937 novella of the same name. Directed and produced by Gary Sinise, the film features Sinise as George Milton, alongside John Malkovich as Lennie Small, with Casey Siemaszko as Curley, John Terry as Slim, Ray Walston as Candy, Joe Morton as Crooks, and Sherilyn Fenn as Curley's wife. Horton Foote adapted the story for film. Its plot centers on George and the mentally disabled Lennie, two farm workers who travel together and dream of one day owning their own land. With their work passes, the two end up on Tyler Ranch. George finds a property for sale, and calculates that they can buy the land at the end of the month with Candy's help. The film explores themes of discrimination, loneliness, and the American Dream.
Of Mice and Men took part in the 1992 Cannes Film Festival, where Sinise was nominated for the Palme d'Or award, given to the director of the best-featured film. After the film debuted in the United States on October 2, 1992, it received positive acclaim from critics.