Cleo Albert O'Donnell (December 10, 1883 – February 15, 1953) was an American football player and coach. He played college football at Holy Cross from 1904 to 1907. He was a football coach at Everett High School (1909–1915), Purdue University (1916–1917), Holy Cross (1919–1930) and Saint Anselm College (1935–1940). His 1914 Everett team has been ranked as the greatest high school football team of all time, finishing with a 13–0 record and outscoring opponents 600 to 0. In 11 years as the head coach at Holy Cross, his teams compiled a record of 69–27–6. O'Donnell has been inducted into the Holy Cross and Saint Anselm Halls of Fame.