Lurene Tuttle (August 29, 1907 – May 28, 1986) was an American character actress and acting coach, who made the transition from vaudeville to radio, and later films and television. Her most enduring impact was as one of network radio's more versatile actresses. Often appearing in 15 shows per week, comedies, dramas, thrillers, soap operas, and crime dramas, she became known as the "First Lady of Radio".
Tuttle died from cancer May 28, 1986, at Encino Hospital. She was survived by a granddaughter, two grandsons, and a great-granddaughter. Memorial services were held June 2, 1986, at Church of the Recessional at Forest Lawn Memorial Park, Glendale.
Her Sam Spade co-star, Howard Duff, who delivered her eulogy, remembered Tuttle: