Masters of Sex is an American period drama television series that premiered on September 29, 2013, on Showtime. It was developed by Michelle Ashford and loosely based on Thomas Maier's biography Masters of Sex. Set in the 1950s through the late 1960s, the series tells the story of Masters and Johnson (Dr. William Masters and Virginia Johnson) who are portrayed by Michael Sheen and Lizzy Caplan. The series has received critical acclaim. It was nominated for a Golden Globe Award for Best Drama Series in 2013. The series was canceled by Showtime on November 30, 2016, after four seasons.