Space Ghost Coast to Coast is an American adult animated parody talk show, created by Mike Lazzo and hosted by the 1960s Hanna-Barbera cartoon character Space Ghost. Though the original 1960s series aired as a standard Hanna-Barbera Saturday-morning superhero cartoon, Space Ghost Coast to Coast was a reboot of the series intended for adults, reinterpreted as a surreal spoof talk show and produced using the original artwork. The first two seasons were presented as a serious talk show with subdued jokes, while the later seasons relied more on surrealism, non-sequitur, and parody.
Space Ghost Coast to Coast is considered to be the first fully produced Cartoon Network original series. It premiered on April 15, 1994, and originally ended on December 17, 1999. The series was revived on May 7, 2001, and was moved to the new Adult Swim late programming block on September 2 of that year, where new episodes premiered until April 12, 2004. Two final seasons were released on GameTap from 2006 to 2008. Over 11 seasons, 108 episodes aired. The series is notable for helping launch the careers of animators Adam Reed, Matt Thompson, Andy Merrill, Jim Fortier, Pete Smith, Michael Ouweleen, Eric Richter, Dave Willis, and Matt Maiellaro.
Space Ghost Coast to Coast had two spinoff series in the form of Cartoon Planet and The Brak Show, and inspired or influenced other series including Sealab 2021; Aqua Teen Hunger Force; Harvey Birdman, Attorney at Law; Perfect Hair Forever; and The Eric Andre Show.